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Hyaluronidase is an enzyme that breaks down cross-linked hyaluronic acid. It causes immediate disruption of its chemical bonds and initiates the process of absorption by the body. It has been used in medicine for over 60 years.
It is used not only in aesthetic medicine, but also in other branches of medicine, such as gynaecology, orthopaedics, oncology and ophthalmology. The US Food and Drug Administration has approved hyaluronidase for the following indications꞉ subcutaneous infusion of fluids (hypodermoclysis), as an agent to accelerate the absorption and dispersion of drugs in subcutaneous tissue or to control extraction, and as an agent to aid the absorption of contrast agents in urinary tract angiography (subcutaneous urography).
- removal of excessive amounts of administered hyaluronic acid (overcorrection);
- long-lasting lumps or unevenness at the site of acid implantation;
- undesirable displacement of the filler;
- undesirable visibility of the filler due to too shallow
- hyaluronic acid deposits;
- intolerance to hyaluronic acid or cross-linking agent.
- pH close to neutral, so there is no burning sensation during administration;
- immediate effect, dissolution of hyaluronic acid;
- does not cause swelling;
- easy to administer.
- allergy to sheep and bovine protein;
- active herpes;
- hypersensitivity to hyaluronidase;
- viral, bacterial and fungal diseases;
- other unidentified skin diseases;
- pregnancy;
- cancer;
- White, sterile, lyophilised powder for solution preparation.
- Dissolve in approx. 10 ml of NaCl.

An allergy test must be performed before administration. Allergy assessment is mandatory because the enzyme hyaluronidase protein may cause an allergic reaction in the patient. The expected result is quick and definitive in most cases. The first effects may be visible after just a few minutes, but if swelling occurs, they may be imperceptible. Do not combine with other active substances.
Use of hyaluronidase
The Polish Society of Aesthetic Medicine (POLME) has presented its position on the use of hyaluronidase by unauthorised persons. It is important to be aware that hyaluronidase is a powerful product.
The use of hyaluronidase is necessary in the treatment of side effects after the injection of hyaluronic acid, one of the most popular wrinkle fillers. In the event of a hyaluronic acid embolism, hyaluronidase must be administered immediately with full anti-shock protection.
Information
EXPIRY DATE: 5 years from the date of manufacture;
STORAGE: it is recommended to store at a temperature of 15-25ºC.
Protect from sunlight.
The products comply with GMP guidelines and are certified in accordance with the Quality Management System according to EN ISO 13485꞉ 2016 and EN ISO 22716꞉ 2008.
* The information contained on this website is provided for informational and commercial purposes only, relating to the product described. Information on raw materials and active ingredients may vary for reasons beyond our control.
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REGON: 542061826
KRS: 0001180057
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